CAS No.: 1050477-31-0
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General description:
Product Name : Finerenone
CAS No.: 1050477-31-0
[Molecular Formula]: C21H22N4O3
[Molecular Weight]: 378.42
Structure Formula:
Synonyms:
Finerenone;BAY 94-8862;Finerone;(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide;BAY948862;Fenaridone;Mr Neri ketone;Finerenone Inn;Finerenone API;Finerenone In-House
Specification:
Appearance: Off-white solid
Assay: Not less than 99.0%
Boiling point: 554.7±50.0 °C
Density: 1.29±0.1 g/cm3
Solubility (25°C): DMSO ≥ 90 mg/mL
Applications:
Finerenone is a novel mineralocorticoid receptor antagonist that has the effect of delaying the progression of chronic kidney disease. Some people may be aware of two other mineralocorticoid receptor antagonists: the diuretic antihypertensive drug spironolactone, and eplerenone.Finerenone is their cognate derivative and is a third-generation mineralocorticoid receptor antagonist. So far, finerenone is the only nonsteroidal mineralocorticoid receptor antagonist to be FDA approved. Finerenone was granted FDA approval on 9 July 2021, followed by the EMA approval on 11 March 2022.
Uses
Finerenone is the first non-steroidal selective mineralocorticoid receptor antagonist, which can be used for the treatment of diabetic nephropathy, chronic kidney disease and end-stage renal disease. It can reduce the proteinuria of patients and improve the glomerular filtration rate.
Biological Activity
Finerenone (FIN, BAY 94-8862) is a highly selective, orally active, nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential to study cardio-renal diseases such as type 2 diabetes and chronic kidney disease.
Important information:
Production capacity: A bulk quantity per months
Delivery : Shipment by Air or Sea
Stock: in stock
Shelf Life: 24 months from manufacture date
Packing:
In plastic bag or fibre drum packing
Please contact us by e-mail sales@haihengpharma.com for quotation requests. Please provide quantity, purity, and any other specific requirements.
http://www.haihengpharma.com/cas-no-1050477-31-0/Custom Synthesis for APIs