Custom Synthesis, The pharmaceutical industry needs a large number of special chemicals, the original production by the pharmaceutical industry, but with the socialization of division of labor and Production technology progress requirements, the pharmaceutical industry will be some of the pharmaceutical intermediates to chemical enterprise production. Pharmaceutical intermediates are fine chemical products, the production of pharmaceutical intermediates has become a major industry in the international chemical industry.

On the one hand, the export of pharmaceutical intermediates is not subject to the restrictions of the importing countries as medicines; On the other hand, many large pharmaceutical companies in the United States and Europe consider importing more reliable pharmaceutical intermediates from developing countries by saving production costs and environmental requirements, and the pharmaceutical intermediates industry has some particularity, Make China in this industry occupies a considerable advantage in the world. This has brought excellent business opportunities to the pharmaceutical intermediates enterprises in our country.

At present, our country needs chemical supporting raw materials and intermediates of more than 2000 kinds each year, the demand is more than 2.5 million tons. After more than 30 years of development, China’s pharmaceutical production needs of chemical raw materials and intermediates basic can be matched, only a small part of the need to import, and due to China’s rich resources, raw materials prices are lower, pharmaceutical intermediates large supply of exports.

Main APIs and Intermediates

1. Antibiotics and intermediates

Antibiotic drugs are divided into β-, sulfa, Quinolones and so on.

⑴β-of Caprolactam Antibiotics

After nearly half a century of development, the β-of Caprolactam in China has formed a complete production system. There are two types of β-, namely penicillin and cephalosporins, and the production of penicillin in our country is in the forefront of the world, and a large number of exports are available. The cephalosporins are basically self-sufficient and can be exported.

At present, almost all of the β-caprolactam antibiotics in our country can be produced, and the cost is very low; β-of the intermediates of the caprolactam antibiotics, except for the ACA and ADCA of the semi synthetic antibiotics, which are required to be partially imported, our country almost all can produce, and large exports.

⑵ Quinolone Antibacterial and intermediates

Fluoroquinolones are a new kind of anti-infective drugs developed in the early 70. Due to the largest dosage, the most widely used traditional antibiotic penicillin for many years, has produced some resistance, some people allergic to penicillin can not be used. However, the bactericidal spectrum of fluoroquinolones is wide, the toxicity is small, and the price is moderate, which has become a kind of antibiotics in recent years. Our country has been developed and has been put into mass production of fluoroquinolones mainly Norfloxacin, ciprofloxacin, Ofloxacin, Norfloxacin, Lomefloxacin, fleroxacin, such as fluorine and sand stars. Among them, Norfloxacin, ciprofloxacin, Ofloxacin, the largest production, accounted for about 98% of the total production of fluoroquinolones in the country.

Quinolones are generally synthesized from fluorine-containing benzene ring rings to be condensed with piperazine (or methyl piperazine) after synthesis of fluorine-containing quinoline compounds. Due to the abundant fluorite in China, it is one of the countries with the largest production of fluorine-containing drugs and intermediates in the world. More than 80% of these intermediates are exported. As a whole, the fluorine-benzene intermediates in China developed earlier, at present, the production capacity is generally surplus, the development of toluene-like intermediates is relatively late in recent years, but for heterocyclic aromatic compounds, especially fluorine-containing pyridine, there are only individual research units and manufacturers in China with the synthesis technology of pyridine-containing intermediates, therefore, Pyridine-containing intermediates will be one of the main directions for the development of fluorine-containing intermediates in China in the next few years.

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Custom Synthesis, The pharmaceutical industry needs a large number of special chemicals, the original production by the pharmaceutical industry, but with the socialization of division of labor and Production technology progress requirements, the pharmaceutical industry will be some of the pharmaceutical intermediates to chemical enterprise production. Pharmaceutical intermediates are fine...