Steroid drugs are the second largest drug

Custom Synthesis, Steroid drugs in the chemical system occupies an important position, mainly for corticosteroids and sex hormones drugs, in addition to anesthesia and treatment of cardiovascular and cerebrovascular diseases. Its discovery and synthesis, together with the discovery and application of antibiotics, has been hailed as the two major advances in the pharmaceutical industry in 20th century. After the 90 ‘s, China has gradually become the world’s steroid drug production Center, the current annual output accounted for about 1/3 of the world’s total production capacity and the actual production of corticosteroids in the world’s first.

“However, from the perspective of product structure, China’s steroid drug industry and foreign advanced level has a larger gap, new product research and development capacity is insufficient, mainly reflected in microbial transformation technology and the breeding of fine strains of key production technology. Prof Wei Dongzhi, for example, has more than 300 varieties of steroid-producing drugs worldwide, while domestic production is only more than 40 species, accounting for only 14% of the world, and mostly in low-grade products.

In this context, the team focused on the important route for the production of steroids by mycobacteria, a number of basic studies have been carried out for many years, which have finally clarified the key mechanisms for the conversion of sterol into a useful steroid drug intermediates, and on this basis, a C19 steroid-$literal Two ketone has been successfully developed. 9α-$literal two ketone and C22 steroidal c20-, and other steroidal pharmaceutical intermediates. These pharmaceutical intermediates can be used to produce almost all types of steroid drugs.